After a horrific alchemy experiment goes wrong in the Elric household, brothers Edward and Alphonse are left in a catastrophic new reality. Ignoring the alchemical principle banning human transmutation, the boys attempted to bring their recently deceased mother back to life. Instead, they suffered brutal personal loss: Alphonse's body disintegrated while Edward lost a leg and then sacrificed an arm to keep Alphonse's soul in the physical realm by binding it to a hulking suit of armor. The brothers are rescued by their neighbor Pinako Rockbell and her granddaughter Winry. Known as a bio-mechanical engineering prodigy, Winry creates prosthetic limbs for Edward by utilizing "automail," a tough, versatile metal used in robots and combat armor. After years of training, the Elric brothers set off on a quest to restore their bodies by locating the Philosopher's Stone—a powerful gem that allows an alchemist to defy the traditional laws of Equivalent Exchange. As Edward becomes an infamous alchemist and gains the nickname "Fullmetal," the boys' journey embroils them in a growing conspiracy that threatens the fate of the world. Two brothers lose their mother to a un-curable disease. With the power of “alchemy”, they use taboo knowledge to resurrect her. The process fails, and as a toll for using this type of alchemy, the older brother, Edward Elric loses his left leg while the younger brother, Alphonse Elric loses his entire body. To save his brother, Edward sacrifices his right arm and is able to affix his brother’s soul to a suit of armor. With the help of a family-friend, Edward receives metal limbs – “Automail” – to replace his lost ones.