In the great city of Metropolis, severe community structures and prejudice dominate a world where humans and robots live together. Unrest and violence increase with each new day. Searching for the scientist Dr. Laughton, suspected to violate human rights by trading organs, the Japanese detective Shunsaku Ban and his nephew Kenichi arrive at Metropolis. In the scientist's laboratory, Kenichi discovers a girl without any memory of her past life. He decides to help her, so they run away together. His uncle follows him and penetrates the dark secrets of the city to find Duke Red, the man ruling from the shadows. Meanwhile, Kenichi desperately tries to protect the mysterious girl from the people hunting her. However, Duke Red and his adoptive son have their own deep reasons for chasing the girl. These reasons are connected to her true identity and the struggle for the domination of Metropolis... Set in the future, Metropolis is a grand city-state populated by humans and robots, the cohabitants of a strictly segmented society. Amidst the chaos created by anti-robot factions, detective Hunsaku Ban and his sidekick Ken'ichi are searching for rebel scientist Dr. Laughton. But when they locate him, his secret laboratory is destroyed by fire under sinister circumstances, and instead Ken'ichi finds Tima, a beautiful young girl bereft of memory and speech, seemingly helpless at the site. Little does he know that Tima is a new top-of the-line android created to take over Metropolis, and that behind her creation lie the ambitions of a powerful man and his fierce desire to reclaim a tragic figure from his past.