On a dark, late night in New York City, Ryu is chased and attacked by assassins. After disposing of them, he finds an I.D. card for the Friedman Company. The next day, it is announced that Dr. Ned Friedman has discovered a cure for cancer. But after providing no information at his press conference, a reporter named Sarah decides to investigate with the help of her friends Robert and Jeff. When passing by Dr. Friedman's house one day, Ryu hears the voice of a young girl calling for help. When Sarah and her entourage investigate the house as well, they run into their colleague, Ryu. Upon that, they discover Dr. Friedman has been conducting experiments on live humans using biotechnology, and that it may have something to do with the power of the Evil Gods, whom Ryu had defeated in the past. But when Ryu's friend, Irene, is kidnapped, he must dawn his role as a Dragon Ninja once again to defeat this new enemy and save her. (Source: ANN)A long time ago, there was a war between the Evil God and the Dragon God. The war finally came to an end when a Dragon Ninja, who had the power of the Dragon God, sealed away the Evil God.Several thousand years later, in New York, a young ninja named Ryu is attacked by a couple of men in black suits wearing white masks. He notices that they are related to someone worshiping the same Evil God of the past and resolves to fight against them before the Evil God is unsealed again.