Although her name means "snow white," Shirayuki is a cheerful, red-haired girl living in the country of Tanbarun who works diligently as an apothecary at her herbal shop. Her life changes drastically when she is noticed by the silly prince of Tanbarun, Prince Raji, who then tries to force her to become his concubine. Unwilling to give up her freedom, Shirayuki cuts her long red hair and escapes into the forest, where she is rescued from Raji by Zen Wistalia, the second prince of a neighboring country, and his two aides. Hoping to repay her debt to the trio someday, Shirayuki sets her sights on pursuing a career as the court herbalist in Zen's country, Clarines. Akagami no Shirayuki-hime depicts Shirayuki's journey toward a new life at the royal palace of Clarines, as well as Zen's endeavor to become a prince worthy of his title. As loyal friendships are forged and deadly enemies formed, Shirayuki and Zen slowly learn to support each other as they walk their own paths. Shirayuki was a young girl born with unique apple-red hair. She meets a famous but foolish Prince Raji, who falls in love with her at first sight and orders her to become his concubine. With nowhere else to go, Shirayuki cuts her hair and escapes to a neighboring country. While traversing through the forests, she meets a young boy, Zen, who helps her after she boldly cures his wounds but then gets poisoned by an apple given to Shirayuki. Meanwhile, Prince Raji sends out henchmen to search for her. What will happen to Shirayuki? What is Zen's true character? A refreshing fantasy story between an optimistic heroine and a prince who constantly stays on her watch