Wild Arms: Twilight Venom

That jumbled piece of architecture, that cacophony of hissing steam and creaking joints, with smoke billowing from it as it moves on its own... That castle is home to the magnificent wizard Howl, infamous for both his magical prowess and for being a womanizer—or so the rumor goes in Sophie Hatter's small town. Sophie, as the plain daughter of a hatmaker, does not expect much from her future and is content with working hard in the shop. However, Sophie's simple life takes a turn for the exciting when she is ensnared in a disturbing situation, and the mysterious wizard appears to rescue her. Unfortunately, this encounter, brief as it may be, spurs the vain and vengeful Witch of the Waste—in a fit of jealousy caused by a past discord with Howl—to put a curse on the maiden, turning her into an old woman. In an endeavor to return to normal, Sophie must accompany Howl and a myriad of eccentric companions—ranging from a powerful fire demon to a hopping scarecrow—in his living castle, on a dangerous adventure as a raging war tears their kingdom apart. [Written by MAL Rewrite]

"In order for something to be obtained, something of equal value must be lost." Alchemy is bound by this Law of Equivalent Exchange—something the young brothers Edward and Alphonse Elric only realize after attempting human transmutation: the one forbidden act of alchemy. They pay a terrible price for their transgression—Edward loses his left leg, Alphonse his physical body. It is only by the desperate sacrifice of Edward's right arm that he is able to affix Alphonse's soul to a suit of armor. Devastated and alone, it is the hope that they would both eventually return to their original bodies that gives Edward the inspiration to obtain metal limbs called "automail" and become a state alchemist, the Fullmetal Alchemist. Three years of searching later, the brothers seek the Philosopher's Stone, a mythical relic that allows an alchemist to overcome the Law of Equivalent Exchange. Even with military allies Colonel Roy Mustang, Lieutenant Riza Hawkeye, and Lieutenant Colonel Maes Hughes on their side, the brothers find themselves caught up in a nationwide conspiracy that leads them not only to the true nature of the elusive Philosopher's Stone, but their country's murky history as well. In between finding a serial killer and racing against time, Edward and Alphonse must ask themselves if what they are doing will make them human again... or take away their humanity. [Written by MAL Rewrite]